Assay Detail
Binding
CHEMBL4726245
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Inhibition of human NEU3 expressed in HEK293A cells as substrate incubated for 1 hr by spectrofluorometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2β-3,4-Unsaturated sialic acid derivatives: Synthesis optimization, and biological evaluation as Newcastle disease virus hemagglutinin-neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.52 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96712 | NEU5AC2EN | — | 1 | 5.62 |
| CHEMBL4745230 | — | — | 1 | 5.41 |
| CHEMBL4792054 | — | — | 1 | - |
| CHEMBL4779317 | — | — | 1 | - |
| CHEMBL4761516 | — | — | 1 | - |
| CHEMBL4746115 | — | — | 1 | - |
| CHEMBL4764169 | — | — | 1 | - |
| CHEMBL4753409 | — | — | 1 | - |
| CHEMBL4743493 | — | — | 1 | - |
| CHEMBL4744597 | — | — | 1 | - |
| CHEMBL4751929 | — | — | 1 | - |
| CHEMBL4750824 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4745230 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4792054 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4779317 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4761516 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4746115 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4764169 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4753409 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4743493 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4744597 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4751929 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4750824 | — | IC50 | > | 1000000.0 | nM | - |