Assay Detail
Binding
CHEMBL4727112
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Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.04 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751100 | — | — | 1 | 9.92 |
| CHEMBL4785201 | — | — | 1 | 9.57 |
| CHEMBL4796461 | — | — | 1 | 9.36 |
| CHEMBL4797814 | — | — | 1 | 8.69 |
| CHEMBL4787579 | — | — | 1 | 8.43 |
| CHEMBL4762419 | — | — | 1 | 8.42 |
| CHEMBL4798535 | — | — | 1 | 8.27 |
| CHEMBL4794645 | — | — | 1 | 8.21 |
| CHEMBL4747041 | — | — | 1 | 8.16 |
| CHEMBL4789620 | — | — | 1 | 8.10 |
| CHEMBL4797177 | — | — | 1 | 8.10 |
| CHEMBL4787251 | — | — | 1 | 8.08 |
| CHEMBL4747836 | — | — | 1 | 7.98 |
| CHEMBL4789172 | — | — | 1 | 7.96 |
| CHEMBL292314 | — | — | 1 | 7.84 |
| CHEMBL4758624 | — | — | 1 | 7.32 |
| CHEMBL4757922 | — | — | 1 | 7.24 |
| CHEMBL4792460 | — | — | 1 | 7.16 |
| CHEMBL4794549 | — | — | 1 | 6.96 |
| CHEMBL4749077 | — | — | 1 | 6.56 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
| CHEMBL4755403 | — | — | 1 | - |
| CHEMBL4747354 | — | — | 1 | - |
| CHEMBL4796696 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751100 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4785201 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4796461 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4797814 | — | IC50 | = | 2.05 | nM | 8.69 |
| CHEMBL4787579 | — | IC50 | = | 3.69 | nM | 8.43 |
| CHEMBL4762419 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4798535 | — | IC50 | = | 5.43 | nM | 8.27 |
| CHEMBL4794645 | — | IC50 | = | 6.23 | nM | 8.21 |
| CHEMBL4747041 | — | IC50 | = | 6.99 | nM | 8.16 |
| CHEMBL4789620 | — | IC50 | = | 7.89 | nM | 8.10 |
| CHEMBL4797177 | — | IC50 | = | 7.94 | nM | 8.10 |
| CHEMBL4787251 | — | IC50 | = | 8.35 | nM | 8.08 |
| CHEMBL4747836 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4789172 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL292314 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4758624 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL4757922 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL4792460 | — | IC50 | = | 69.8 | nM | 7.16 |
| CHEMBL4794549 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4749077 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL95 | TACRINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4755403 | — | IC50 | - | — | - | |
| CHEMBL4747354 | — | IC50 | - | — | - | |
| CHEMBL4796696 | — | IC50 | = | 101000.0 | nM | - |