Assay Detail
Binding
CHEMBL4727432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of YES1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.31 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4106978 | — | — | 1 | 7.92 |
| CHEMBL4108687 | — | — | 1 | 7.52 |
| CHEMBL4749037 | — | — | 1 | 7.46 |
| CHEMBL4114929 | — | — | 1 | 7.27 |
| CHEMBL4107779 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4106978 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4108687 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4749037 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4114929 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4107779 | — | IC50 | = | 430.0 | nM | 6.37 |