Assay Detail
Binding
CHEMBL4727484
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Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.89 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634860 | — | — | 1 | 8.40 |
| CHEMBL4748638 | — | — | 1 | 7.42 |
| CHEMBL4740968 | — | — | 1 | 7.26 |
| CHEMBL4792072 | — | — | 1 | 7.03 |
| CHEMBL4755173 | — | — | 1 | 7.01 |
| CHEMBL4783510 | — | — | 1 | 6.96 |
| CHEMBL4796453 | — | — | 1 | 6.92 |
| CHEMBL4782200 | — | — | 1 | 6.82 |
| CHEMBL4776103 | — | — | 1 | 6.66 |
| CHEMBL4740820 | — | — | 1 | 6.52 |
| CHEMBL4745239 | — | — | 1 | 5.92 |
| CHEMBL4743698 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634860 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4748638 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4740968 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4792072 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4755173 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4783510 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4796453 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4782200 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4776103 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4740820 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4745239 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4743698 | — | IC50 | = | 2000.0 | nM | 5.70 |