Assay Detail
Binding
CHEMBL4727716
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Inhibition of SPAK (unknown origin) by ELISA
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
STE20/SPS1-related proline-alanine-rich protein kinase (CHEMBL1163108) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.77 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792789 | — | — | 1 | 7.30 |
| CHEMBL4762099 | — | — | 1 | 6.96 |
| CHEMBL4759888 | — | — | 1 | 6.62 |
| CHEMBL4797256 | — | — | 1 | 6.58 |
| CHEMBL4751500 | — | — | 1 | 6.19 |
| CHEMBL4759820 | — | — | 1 | 6.00 |
| CHEMBL4753158 | — | — | 1 | 5.96 |
| CHEMBL4750439 | — | — | 1 | 5.85 |
| CHEMBL4758154 | — | — | 1 | 5.82 |
| CHEMBL4783530 | — | — | 1 | 5.82 |
| CHEMBL4747390 | — | — | 1 | 5.75 |
| CHEMBL4793138 | — | — | 1 | 5.70 |
| CHEMBL4748104 | — | — | 1 | 5.68 |
| CHEMBL4744527 | — | — | 1 | 5.68 |
| CHEMBL4795291 | — | — | 1 | 5.64 |
| CHEMBL4757952 | — | — | 1 | 5.62 |
| CHEMBL4748683 | — | — | 1 | 5.57 |
| CHEMBL4757062 | — | — | 1 | 5.55 |
| CHEMBL4796271 | — | — | 1 | 5.50 |
| CHEMBL4762871 | — | — | 1 | 5.46 |
| CHEMBL4783506 | — | — | 1 | 5.36 |
| CHEMBL1814047 | — | — | 1 | 5.35 |
| CHEMBL4641560 | — | — | 1 | 5.31 |
| CHEMBL4796688 | — | — | 1 | 5.29 |
| CHEMBL4793886 | — | — | 1 | 5.25 |
| CHEMBL4758811 | — | — | 1 | 5.24 |
| CHEMBL4781027 | — | — | 1 | 4.77 |
| CHEMBL4751625 | — | — | 1 | - |
| CHEMBL4743960 | — | — | 1 | - |
| CHEMBL4744081 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792789 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4762099 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4759888 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4797256 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4751500 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4759820 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4753158 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4750439 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4758154 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4783530 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4747390 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4793138 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4748104 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4744527 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4795291 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4757952 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4748683 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4757062 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4796271 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4762871 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4783506 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1814047 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4641560 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4796688 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4793886 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4758811 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4781027 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4749571 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4745477 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4759749 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4753349 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4778943 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4797907 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4744081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4743960 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4751625 | — | IC50 | > | 50000.0 | nM | - |