Assay Detail
Binding
CHEMBL4727763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDGFRbeta using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.44 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740381 | — | — | 1 | 5.90 |
| CHEMBL4742906 | — | — | 1 | 5.55 |
| CHEMBL4778971 | — | — | 1 | 5.16 |
| CHEMBL4788859 | — | — | 1 | 5.13 |
| CHEMBL4786529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740381 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4742906 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4778971 | — | IC50 | = | 6903.0 | nM | 5.16 |
| CHEMBL4788859 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL4786529 | — | IC50 | > | 10000.0 | nM | - |