Assay Detail
Binding
CHEMBL4729675
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Inhibition of FBPase (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784789 | — | — | 1 | 7.62 |
| CHEMBL595149 | — | — | 1 | 6.48 |
| CHEMBL207095 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784789 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL595149 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL207095 | — | IC50 | = | 3400.0 | nM | 5.47 |