Assay Detail
Binding
CHEMBL4729717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.70 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 8.22 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 8.00 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.97 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.89 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 12.92 | nM | 7.89 |
| CHEMBL939 | GEFITINIB | IC50 | = | 37.0 | nM | 7.43 |