Assay Detail
Binding
CHEMBL4730989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 in human HEL cells harboring JAK2 V617F mutant assessed as decrease in metabolic activity measured after 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.00 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790505 | — | — | 1 | 6.30 |
| CHEMBL2179387 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790505 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2179387 | — | IC50 | = | 2000.0 | nM | 5.70 |