Assay Detail
Functional
CHEMBL4731089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 infected in human MT4 cells incubated for 7 days by fully automated chemiluminescent enzyme immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.30 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744116 | — | — | 1 | 9.00 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.34 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.30 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.57 |
| CHEMBL4743665 | — | — | 1 | - |
| CHEMBL4755541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744116 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4743665 | — | IC50 | = | 0.0045 | nM | - |
| CHEMBL4755541 | — | IC50 | = | 0.0042 | nM | - |