Assay Detail
Functional
CHEMBL4731093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 DRVR P30 infected in human MT4 cells incubated for 7 days by fully automated chemiluminescent enzyme immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.72 | 10.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743665 | — | — | 1 | 10.41 |
| CHEMBL4744116 | — | — | 1 | 6.37 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 6.37 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | - |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | - |
| CHEMBL4755541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743665 | — | IC50 | = | 0.039 | nM | 10.41 |
| CHEMBL4744116 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL729 | LOPINAVIR | IC50 | > | 1000.0 | nM | - |
| CHEMBL1163 | ATAZANAVIR | IC50 | > | 1000.0 | nM | - |
| CHEMBL4755541 | — | IC50 | = | 0.0047 | nM | - |