Assay Detail
Toxicity
CHEMBL4731278
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Hepatotoxicity in rat liver mitochondria assessed as inhibition of mitochondrial respiration by measuring mitochondrial respiratory control ratio of oxygen consumption in presence of substrate and ADP to rate after complete conversion of ADP to ATP by Clark-type oxygen electrode method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Mitochondria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.64 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 5.51 |
| CHEMBL4781629 | — | — | 1 | 5.44 |
| CHEMBL4753182 | — | — | 1 | 5.18 |
| CHEMBL4781818 | — | — | 1 | 4.92 |
| CHEMBL4748804 | — | — | 1 | 4.75 |
| CHEMBL4796568 | — | — | 1 | 4.62 |
| CHEMBL4594446 | DOTINURAD | 3.0 | 1 | 4.57 |
| CHEMBL4744854 | — | — | 1 | 4.51 |
| CHEMBL4790389 | — | — | 1 | 4.43 |
| CHEMBL4785752 | — | — | 1 | 4.40 |
| CHEMBL4796932 | — | — | 1 | 4.28 |
| CHEMBL4744184 | — | — | 1 | 4.26 |
| CHEMBL4740995 | — | — | 1 | 4.23 |
| CHEMBL4760971 | — | — | 1 | 4.23 |
| CHEMBL4778323 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4781629 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4753182 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4781818 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4748804 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4796568 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4594446 | DOTINURAD | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4744854 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4790389 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4785752 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4796932 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL4744184 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL4740995 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4760971 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4778323 | — | IC50 | = | 63000.0 | nM | 4.20 |