Assay Detail
Binding
CHEMBL4731344
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Inhibition of recombinant human autotaxin assessed as reduction in LPA production using LPC as substrate after 2 hrs by Rapidfire-MS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Potential of Autotaxin Inhibitors in Treatment of Interstitial Lung Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.39 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759980 | — | — | 1 | 8.70 |
| CHEMBL4794512 | — | — | 1 | 8.52 |
| CHEMBL4760475 | — | — | 1 | 8.40 |
| CHEMBL4796631 | — | — | 1 | 8.40 |
| CHEMBL4792073 | — | — | 1 | 8.40 |
| CHEMBL4746361 | — | — | 1 | 8.22 |
| CHEMBL4784550 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759980 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4794512 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4760475 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4796631 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4792073 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4746361 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4784550 | — | IC50 | = | 8.0 | nM | 8.10 |