Assay Detail
Binding
CHEMBL4731345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATX in human whole blood assessed as reduction in LPA level after 1 hr by rapidFire based MS/MS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic Potential of Autotaxin Inhibitors in Treatment of Interstitial Lung Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796631 | — | — | 1 | 8.05 |
| CHEMBL4794512 | — | — | 1 | 7.48 |
| CHEMBL4746361 | — | — | 1 | 7.34 |
| CHEMBL4759980 | — | — | 1 | 7.26 |
| CHEMBL4784550 | — | — | 1 | 6.73 |
| CHEMBL4760475 | — | — | 1 | 6.70 |
| CHEMBL4792073 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796631 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4794512 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4746361 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4759980 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4784550 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4760475 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL4792073 | — | IC50 | = | 264.0 | nM | 6.58 |