Assay Detail
Binding
CHEMBL4731348
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Inhibition of recombinant human His-tagged KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and measured after 15 mins by ADP-Glo kinase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel KIF18A Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.86 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755023 | — | — | 1 | 7.92 |
| CHEMBL4784192 | — | — | 1 | 7.92 |
| CHEMBL4777623 | — | — | 1 | 7.85 |
| CHEMBL4752657 | — | — | 1 | 7.85 |
| CHEMBL4777759 | — | — | 1 | 7.80 |
| CHEMBL4746340 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755023 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4784192 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4777623 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4752657 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4777759 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4746340 | — | IC50 | = | 16.0 | nM | 7.80 |