Assay Detail
Binding
CHEMBL4731355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VMAT2 in rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Synaptic vesicular amine transporter (CHEMBL4828) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Biotransformation: Impact and Application of Metabolism in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.05 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754647 | — | — | 1 | 8.70 |
| CHEMBL576222 | DIHYDROTETRABENAZINE | -1.0 | 1 | 8.70 |
| CHEMBL4792500 | — | — | 1 | 8.01 |
| CHEMBL4752068 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754647 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL576222 | DIHYDROTETRABENAZINE | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL4792500 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL4752068 | — | Ki | = | 160.0 | nM | 6.80 |