Assay Detail
Binding
CHEMBL4732274
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Inhibition of human tyrosinase assessed as reduction in L-dopaquinone-MBTH complex formation using L-DOPA as substrate measured for 10 mins by spectrophotometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.46 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 5.66 |
| CHEMBL4741095 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4741095 | — | IC50 | = | 5600.0 | nM | 5.25 |