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Assay Detail

CHEMBL4732476

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to c-Myc G-quadruplex DNA (unknown origin) assessed as dissociation constant incubated for 5 mins by UV- vis spectrophotometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Target

quadruplex DNA (CHEMBL3832742)
Type NUCLEIC-ACID
Organism Homo sapiens

Publication

Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA
Singu, Padma S., Chilakamarthi, Ushasri, Mahadik, Namita S., Keerti, Bhamidipati, Valipenta, Narasimhulu, Mokale, Santosh N., Nagesh, Narayana, Kumbhare, Ravindra M.
RSC Med Chem (2021) 12 : 416 -429
PubMed 34046624 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 4.10 4.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4759761 1 4.10
CHEMBL4786759 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4759761 Kd = 79230.0 nM 4.10
CHEMBL4786759 Kd = 113000.0 nM -