Assay Detail
ADMET
CHEMBL4732744
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| IC50 | 2 | 4.89 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795072 | — | — | 1 | 5.22 |
| CHEMBL4741834 | — | — | 1 | 4.55 |
| CHEMBL4776429 | — | — | 1 | - |
| CHEMBL4758105 | — | — | 1 | - |
| CHEMBL4781165 | — | — | 1 | - |
| CHEMBL4799185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795072 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4741834 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4776429 | — | Activity | - | — | - | |
| CHEMBL4758105 | — | Activity | - | — | - | |
| CHEMBL4781165 | — | Activity | - | — | - | |
| CHEMBL4799185 | — | Activity | - | — | - |