Assay Detail
Functional
CHEMBL4733239
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Antiproliferative activity against human HCT116 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.81 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798567 | — | — | 1 | 8.66 |
| CHEMBL498271 | — | — | 1 | 8.62 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.59 |
| CHEMBL4761241 | — | — | 1 | 7.70 |
| CHEMBL4761195 | — | — | 1 | 7.40 |
| CHEMBL4781369 | — | — | 1 | 7.16 |
| CHEMBL4800404 | — | — | 1 | 7.16 |
| CHEMBL4743770 | — | — | 1 | 7.10 |
| CHEMBL4740252 | — | — | 1 | 7.04 |
| CHEMBL4783656 | — | — | 1 | 6.76 |
| CHEMBL4749694 | — | — | 1 | 6.57 |
| CHEMBL4787254 | — | — | 1 | 6.40 |
| CHEMBL4798027 | — | — | 1 | 6.31 |
| CHEMBL4757846 | — | — | 1 | 5.89 |
| CHEMBL4759987 | — | — | 1 | 5.49 |
| CHEMBL179051 | — | — | 1 | 5.34 |
| CHEMBL4780161 | — | — | 1 | 5.31 |
| CHEMBL4742924 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798567 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL498271 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4761241 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4761195 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4781369 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4800404 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4743770 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4740252 | — | IC50 | = | 90.2 | nM | 7.04 |
| CHEMBL4783656 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4749694 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL4787254 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4798027 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4757846 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4759987 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL179051 | — | IC50 | = | 4564.0 | nM | 5.34 |
| CHEMBL4780161 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL4742924 | — | IC50 | = | 7630.0 | nM | 5.12 |