Assay Detail
Binding
CHEMBL4733345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate incubated for 30 mins by microplate reader assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.44 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757403 | — | — | 1 | 7.75 |
| CHEMBL4747585 | — | — | 1 | 7.52 |
| CHEMBL4758717 | — | — | 1 | 7.51 |
| CHEMBL4755606 | — | — | 1 | 7.44 |
| CHEMBL4798508 | — | — | 1 | 7.31 |
| CHEMBL4789288 | — | — | 1 | 7.13 |
| CHEMBL4758976 | — | — | 1 | 7.11 |
| CHEMBL4536045 | — | — | 1 | 7.09 |
| CHEMBL4798272 | — | — | 1 | 6.89 |
| CHEMBL570812 | — | — | 1 | 6.89 |
| CHEMBL4435479 | — | — | 1 | 6.85 |
| CHEMBL4746545 | — | — | 1 | 6.56 |
| CHEMBL4794653 | — | — | 1 | 6.43 |
| CHEMBL4753531 | — | — | 1 | 6.12 |
| CHEMBL4784401 | — | — | 1 | 6.00 |
| CHEMBL4753368 | — | — | 1 | 5.70 |
| CHEMBL4754790 | — | — | 1 | 5.64 |
| CHEMBL4784941 | — | — | 1 | 5.48 |
| CHEMBL4755379 | — | — | 1 | 5.47 |
| CHEMBL4763206 | — | — | 1 | 5.37 |
| CHEMBL4758281 | — | — | 1 | 5.36 |
| CHEMBL4752739 | — | — | 1 | 5.35 |
| CHEMBL4755839 | — | — | 1 | 5.09 |
| CHEMBL4778126 | — | — | 1 | - |
| CHEMBL4757544 | — | — | 1 | - |
| CHEMBL4763651 | — | — | 1 | - |
| CHEMBL4755309 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757403 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4747585 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4758717 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4755606 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4798508 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4789288 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4758976 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4536045 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4798272 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL570812 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4435479 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4746545 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4794653 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL4753531 | — | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL4784401 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4753368 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4754790 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4784941 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4755379 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4763206 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4758281 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4752739 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4755839 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4778126 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4757544 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763651 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4755309 | — | IC50 | > | 10000.0 | nM | - |