Assay Detail
Functional
CHEMBL4733355
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Antiproliferative activity against human HCT116 cells as reduction in cell growth measured after 96 hrs by Celltiter-glo luminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.92 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747585 | — | — | 1 | 5.29 |
| CHEMBL4755606 | — | — | 1 | 5.28 |
| CHEMBL4757403 | — | — | 1 | 4.82 |
| CHEMBL4798508 | — | — | 1 | 4.77 |
| CHEMBL570812 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747585 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4755606 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4757403 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4798508 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL570812 | — | IC50 | = | 38000.0 | nM | 4.42 |