Assay Detail
Binding
CHEMBL4733430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σR/TMEM97 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.92 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.48 |
| CHEMBL4739972 | — | — | 1 | 6.79 |
| CHEMBL4778965 | — | — | 1 | 5.50 |
| CHEMBL4759158 | — | — | 1 | - |
| CHEMBL4749663 | — | — | 1 | - |
| CHEMBL4778377 | — | — | 1 | - |
| CHEMBL4763056 | — | — | 1 | - |
| CHEMBL4740343 | — | — | 1 | - |
| CHEMBL4796195 | — | — | 1 | - |
| CHEMBL4747537 | — | — | 1 | - |
| CHEMBL4744466 | — | — | 1 | - |
| CHEMBL4760742 | — | — | 1 | - |
| CHEMBL4744206 | — | — | 1 | - |
| CHEMBL4746910 | — | — | 1 | - |
| CHEMBL4761905 | — | — | 1 | - |
| CHEMBL4765186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.27 | nM | 8.48 |
| CHEMBL4739972 | — | Ki | = | 160.2 | nM | 6.79 |
| CHEMBL4778965 | — | Ki | = | 3192.0 | nM | 5.50 |
| CHEMBL4759158 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4749663 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4778377 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4763056 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4740343 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4796195 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4747537 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4744466 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4760742 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4744206 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4746910 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4761905 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4765186 | — | Ki | > | 1000.0 | nM | - |