Assay Detail
Functional
CHEMBL4733439
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Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.44 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122406 | — | — | 1 | 4.97 |
| CHEMBL340558 | — | — | 1 | 4.75 |
| CHEMBL123034 | — | — | 1 | 4.66 |
| CHEMBL124181 | — | — | 1 | 4.49 |
| CHEMBL421268 | — | — | 1 | 4.33 |
| CHEMBL333985 | — | — | 1 | 4.26 |
| CHEMBL125883 | — | — | 1 | 4.04 |
| CHEMBL331343 | — | — | 1 | 4.01 |
| CHEMBL124942 | — | — | 1 | - |
| CHEMBL125650 | — | — | 1 | - |
| CHEMBL125021 | — | — | 1 | - |
| CHEMBL339091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122406 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL340558 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL123034 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL124181 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL421268 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL333985 | — | IC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL125883 | — | IC50 | = | 92300.0 | nM | 4.04 |
| CHEMBL331343 | — | IC50 | = | 96600.0 | nM | 4.01 |
| CHEMBL124942 | — | IC50 | = | 100900.0 | nM | - |
| CHEMBL125650 | — | IC50 | = | 155500.0 | nM | - |
| CHEMBL125021 | — | IC50 | = | 184800.0 | nM | - |
| CHEMBL339091 | — | IC50 | = | 124700.0 | nM | - |