Assay Detail
Binding
CHEMBL4733465
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Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.10 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4760795 | — | — | 1 | 6.24 |
| CHEMBL4798972 | — | — | 1 | 6.06 |
| CHEMBL4798703 | — | — | 1 | 5.32 |
| CHEMBL4778728 | — | — | 1 | 5.31 |
| CHEMBL1221925 | — | — | 1 | 5.27 |
| CHEMBL4756518 | — | — | 1 | 5.18 |
| CHEMBL4783894 | — | — | 1 | 5.15 |
| CHEMBL4791718 | — | — | 1 | 5.11 |
| CHEMBL4750896 | — | — | 1 | 5.10 |
| CHEMBL4757527 | — | — | 1 | 5.09 |
| CHEMBL4786348 | — | — | 1 | 5.08 |
| CHEMBL4780621 | — | — | 1 | 5.07 |
| CHEMBL4762664 | — | — | 1 | 4.78 |
| CHEMBL4793537 | — | — | 1 | 4.71 |
| CHEMBL4782653 | — | — | 1 | 4.62 |
| CHEMBL4759493 | — | — | 1 | 4.57 |
| CHEMBL4754929 | — | — | 1 | 4.55 |
| CHEMBL4794500 | — | — | 1 | 4.44 |
| CHEMBL4747211 | — | — | 1 | 4.43 |
| CHEMBL4760657 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4760795 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL4798972 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL4798703 | — | Ki | = | 4790.0 | nM | 5.32 |
| CHEMBL4778728 | — | Ki | = | 4860.0 | nM | 5.31 |
| CHEMBL1221925 | — | Ki | = | 5380.0 | nM | 5.27 |
| CHEMBL4756518 | — | Ki | = | 6560.0 | nM | 5.18 |
| CHEMBL4783894 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL4791718 | — | Ki | = | 7790.0 | nM | 5.11 |
| CHEMBL4750896 | — | Ki | = | 7920.0 | nM | 5.10 |
| CHEMBL4757527 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL4786348 | — | Ki | = | 8230.0 | nM | 5.08 |
| CHEMBL4780621 | — | Ki | = | 8570.0 | nM | 5.07 |
| CHEMBL4762664 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL4793537 | — | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL4782653 | — | Ki | = | 23700.0 | nM | 4.62 |
| CHEMBL4759493 | — | Ki | = | 26800.0 | nM | 4.57 |
| CHEMBL4754929 | — | Ki | = | 28400.0 | nM | 4.55 |
| CHEMBL4794500 | — | Ki | = | 36400.0 | nM | 4.44 |
| CHEMBL4747211 | — | Ki | = | 36700.0 | nM | 4.43 |
| CHEMBL4760657 | — | Ki | = | 41400.0 | nM | 4.38 |