Assay Detail
Binding
CHEMBL4733668
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Inhibition of HDAC3 (unknown origin) by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.87 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755061 | — | — | 1 | 7.44 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.40 |
| CHEMBL4794499 | — | — | 1 | 6.79 |
| CHEMBL4747126 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755061 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL4794499 | — | IC50 | = | 161.2 | nM | 6.79 |
| CHEMBL4747126 | — | IC50 | = | 1440.5 | nM | 5.84 |