Assay Detail
Functional
CHEMBL4733965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human H1299 cells incubated for 48 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.90 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 6.31 |
| CHEMBL4744561 | — | — | 1 | 4.74 |
| CHEMBL4788522 | — | — | 1 | 4.66 |
| CHEMBL4746177 | — | — | 1 | 4.43 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4744561 | — | IC50 | = | 18250.0 | nM | 4.74 |
| CHEMBL4788522 | — | IC50 | = | 21760.0 | nM | 4.66 |
| CHEMBL4746177 | — | IC50 | = | 36740.0 | nM | 4.43 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | IC50 | = | 45020.0 | nM | 4.35 |