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Assay Detail

CHEMBL4734224

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity against Trypanosoma brucei rhodesiense STIB900 incubated for 70 hrs by Alamar blue assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
Petritsch M,Seebacher W,Mohsin NU,Dolensky J,Hochegger P,Kaiser M,Mäser P,Belaj F,Saf R,Kretschmer N,Alajlani M,Brantner A,Bauer R,Schühly W,Weis R
Eur J Med Chem (2021) 210 : 112969 -112969
PubMed 33148495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.82 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL166 MELARSOPROL 3.0 1 8.41
CHEMBL4781568 1 7.70
CHEMBL4789582 1 7.62
CHEMBL4755154 1 7.38
CHEMBL4751060 1 7.36
CHEMBL4759041 1 7.28
CHEMBL4799168 1 7.20
CHEMBL4755529 1 7.00
CHEMBL4760417 1 6.96
CHEMBL4788169 1 6.92
CHEMBL4745731 1 6.89
CHEMBL4757566 1 6.85
CHEMBL4792376 1 6.77
CHEMBL4745851 1 6.75
CHEMBL4787008 1 6.50
CHEMBL4755356 1 6.38
CHEMBL4789400 1 6.30
CHEMBL4797554 1 5.99
CHEMBL4741972 1 5.26
CHEMBL4759661 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL166 MELARSOPROL IC50 = 3.9 nM 8.41
CHEMBL4781568 IC50 = 20.0 nM 7.70
CHEMBL4789582 IC50 = 24.0 nM 7.62
CHEMBL4755154 IC50 = 42.0 nM 7.38
CHEMBL4751060 IC50 = 44.0 nM 7.36
CHEMBL4759041 IC50 = 52.0 nM 7.28
CHEMBL4799168 IC50 = 63.0 nM 7.20
CHEMBL4755529 IC50 = 100.0 nM 7.00
CHEMBL4760417 IC50 = 110.0 nM 6.96
CHEMBL4788169 IC50 = 120.0 nM 6.92
CHEMBL4745731 IC50 = 130.0 nM 6.89
CHEMBL4757566 IC50 = 140.0 nM 6.85
CHEMBL4792376 IC50 = 170.0 nM 6.77
CHEMBL4745851 IC50 = 180.0 nM 6.75
CHEMBL4787008 IC50 = 320.0 nM 6.50
CHEMBL4755356 IC50 = 420.0 nM 6.38
CHEMBL4789400 IC50 = 500.0 nM 6.30
CHEMBL4797554 IC50 = 1030.0 nM 5.99
CHEMBL4741972 IC50 = 5450.0 nM 5.26
CHEMBL4759661 IC50 = 11000.0 nM 4.96