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Assay Detail

CHEMBL4735513

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-375
Confidence 1 — Organism
Curated By Autocuration

Target

A-375 (CHEMBL613859)
Type CELL-LINE
Organism Homo sapiens

Publication

Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action.
Patinote C,Deleuze-Masquéfa C,Kaddour KH,Vincent LA,Larive R,Zghaib Z,Guichou JF,Assaf MD,Cuq P,Bonnet PA
Eur J Med Chem (2021) 212 : 113031 -113031
PubMed 33309473 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 6.27 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4781226 1 8.52
CHEMBL4752269 1 7.52
CHEMBL4748074 1 7.22
CHEMBL3415553 1 6.86
CHEMBL3785682 1 6.71
CHEMBL4745168 1 6.70
CHEMBL557421 1 6.42
CHEMBL4790070 1 6.38
CHEMBL4787203 1 5.89
CHEMBL4746091 1 5.77
CHEMBL3785910 1 5.63
CHEMBL4785031 1 5.53
CHEMBL4746610 1 5.46
CHEMBL4755515 1 5.25
CHEMBL4745457 1 5.25
CHEMBL4762991 1 5.16
CHEMBL4216993 1 -
CHEMBL4211938 1 -
CHEMBL4213228 1 -
CHEMBL4213700 1 -
CHEMBL4793220 1 -
CHEMBL4799444 1 -
CHEMBL4748946 1 -
CHEMBL4777440 1 -
CHEMBL4762180 1 -
CHEMBL4758745 1 -
CHEMBL4787642 1 -
CHEMBL4759596 1 -
CHEMBL3785466 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4781226 IC50 = 3.0 nM 8.52
CHEMBL4752269 IC50 = 30.0 nM 7.52
CHEMBL4748074 IC50 = 60.0 nM 7.22
CHEMBL3415553 IC50 = 139.0 nM 6.86
CHEMBL3785682 IC50 = 193.0 nM 6.71
CHEMBL4745168 IC50 = 199.0 nM 6.70
CHEMBL557421 IC50 = 383.0 nM 6.42
CHEMBL4790070 IC50 = 414.0 nM 6.38
CHEMBL4787203 IC50 = 1284.0 nM 5.89
CHEMBL4746091 IC50 = 1704.0 nM 5.77
CHEMBL3785910 IC50 = 2354.0 nM 5.63
CHEMBL4785031 IC50 = 2929.0 nM 5.53
CHEMBL4746610 IC50 = 3493.0 nM 5.46
CHEMBL4755515 IC50 = 5694.0 nM 5.25
CHEMBL4745457 IC50 = 5588.0 nM 5.25
CHEMBL4762991 IC50 = 6909.0 nM 5.16
CHEMBL4216993 IC50 > 10000.0 nM -
CHEMBL4211938 IC50 > 10000.0 nM -
CHEMBL4213228 IC50 > 10000.0 nM -
CHEMBL4213700 IC50 > 10000.0 nM -
CHEMBL4793220 IC50 > 10000.0 nM -
CHEMBL4799444 IC50 > 10000.0 nM -
CHEMBL4748946 IC50 > 10000.0 nM -
CHEMBL4777440 IC50 > 10000.0 nM -
CHEMBL4762180 IC50 > 10000.0 nM -
CHEMBL4758745 IC50 > 10000.0 nM -
CHEMBL4787642 IC50 > 10000.0 nM -
CHEMBL4759596 IC50 > 10000.0 nM -
CHEMBL3785466 IC50 > 10000.0 nM -