Assay Detail
ADMET
CHEMBL4735888
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Agonist activity at recombinant rat GluN1a/GluN2B receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/glutamate-induced channel current at -40 mV holding potential by two-electrode voltage clamp method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.99 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365742 | — | — | 1 | 7.10 |
| CHEMBL4796331 | — | — | 1 | 6.05 |
| CHEMBL4755350 | — | — | 1 | 6.00 |
| CHEMBL4751973 | — | — | 1 | 5.96 |
| CHEMBL4758283 | — | — | 1 | 5.82 |
| CHEMBL2365794 | — | — | 1 | 5.00 |
| CHEMBL4792263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365742 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4796331 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4755350 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4751973 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4758283 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2365794 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4792263 | — | EC50 | - | — | - |