Compound Detail
CHEMBL4755350
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Basic Information
| ChEMBL ID | CHEMBL4755350 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PKXJZCANRQBMSM-VJJSXZLQSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
205.2
MW (Da)
-0.58
ALogP
4
HBA
4
HBD
100.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.52 | 5.86 | 300.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 300.0 | nM | 6.52 | Agonist activity at recombinant rat GluN1a/GluN2D receptor expressed in Xenopus ... | 33383257 |
| Unchecked | EC50 | = | 1000.0 | nM | 6.0 | Agonist activity at recombinant rat GluN1a/GluN2B receptor expressed in Xenopus ... | 33383257 |
| Unchecked | EC50 | = | 2500.0 | nM | 5.6 | Agonist activity at recombinant rat GluN1a/GluN2C receptor expressed in Xenopus ... | 33383257 |
| Unchecked | EC50 | = | 4800.0 | nM | 5.32 | Agonist activity at recombinant rat GluN1a/GluN2A receptor expressed in Xenopus ... | 33383257 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33383257 | 10.1016/j.ejmech.2020.113099 | Unchecked | 8 |
Data from ChEMBL 36 via Core Engine