Assay Detail
Binding
CHEMBL4736111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human SIRT2 using KTcr-I as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs in presence of NAD+ by fluorescence photometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.47 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595354 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595354 | — | IC50 | = | 33990.0 | nM | 4.47 |