Assay Detail
Binding
CHEMBL4736124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5HT6R expressed in HEK293 cell membranes incubated for 1 hr by micro-beta plate reader based analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imidazopyridine-Based 5-HT Receptor Neutral Antagonists: Impact of N-Benzyl and N-Phenylsulfonyl Fragments on Different Receptor Conformational States.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756814 | — | — | 1 | 9.00 |
| CHEMBL4760105 | — | — | 1 | 9.00 |
| CHEMBL4760545 | — | — | 1 | 9.00 |
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 8.85 |
| CHEMBL4777550 | — | — | 1 | 8.70 |
| CHEMBL4756098 | — | — | 1 | 8.70 |
| CHEMBL4759927 | — | — | 1 | 8.52 |
| CHEMBL4743983 | — | — | 1 | 8.52 |
| CHEMBL4742804 | — | — | 1 | 8.52 |
| CHEMBL4756605 | — | — | 1 | 8.00 |
| CHEMBL4799851 | — | — | 1 | 7.77 |
| CHEMBL4783584 | — | — | 1 | 7.64 |
| CHEMBL4746063 | — | — | 1 | 7.43 |
| CHEMBL4758494 | — | — | 1 | 7.39 |
| CHEMBL4784080 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756814 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4760105 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4760545 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4777550 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4756098 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4759927 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4743983 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4742804 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4756605 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4799851 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4783584 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4746063 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL4758494 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4784080 | — | Ki | = | 119.0 | nM | 6.92 |