Assay Detail
Functional
CHEMBL4736708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Ligand-Biased Agonists of S1P: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.47 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 9.17 |
| CHEMBL4752394 | — | — | 1 | 8.44 |
| CHEMBL4786296 | — | — | 1 | 8.31 |
| CHEMBL3806205 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL4752394 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4786296 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3806205 | — | EC50 | = | 10.7 | nM | 7.97 |