Assay Detail
Functional
CHEMBL4736749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess method
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.90 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754280 | — | — | 1 | 5.63 |
| CHEMBL4787337 | — | — | 1 | 5.50 |
| CHEMBL4746923 | — | — | 1 | 5.24 |
| CHEMBL4787528 | — | — | 1 | 5.21 |
| CHEMBL4760099 | — | — | 1 | 5.21 |
| CHEMBL4776804 | — | — | 1 | 5.20 |
| CHEMBL4796299 | — | — | 1 | 5.16 |
| CHEMBL4762564 | — | — | 1 | 5.13 |
| CHEMBL4765212 | — | — | 1 | 5.05 |
| CHEMBL4758999 | — | — | 1 | 5.01 |
| CHEMBL4784157 | — | — | 1 | 4.98 |
| CHEMBL4758518 | — | — | 1 | 4.96 |
| CHEMBL4794790 | — | — | 1 | 4.92 |
| CHEMBL4760249 | — | — | 1 | 4.90 |
| CHEMBL4740881 | — | — | 1 | 4.88 |
| CHEMBL4790250 | — | — | 1 | 4.88 |
| CHEMBL4753647 | — | — | 1 | 4.88 |
| CHEMBL4780025 | — | — | 1 | 4.86 |
| CHEMBL4781138 | — | — | 1 | 4.86 |
| CHEMBL4755623 | — | — | 1 | 4.83 |
| CHEMBL4763269 | — | — | 1 | 4.82 |
| CHEMBL4782692 | — | — | 1 | 4.82 |
| CHEMBL4797207 | — | — | 1 | 4.82 |
| CHEMBL4794563 | — | — | 1 | 4.82 |
| CHEMBL4784929 | — | — | 1 | 4.81 |
| CHEMBL4757769 | — | — | 1 | 4.81 |
| CHEMBL4745640 | — | — | 1 | 4.78 |
| CHEMBL4762094 | — | — | 1 | 4.77 |
| CHEMBL4799029 | — | — | 1 | 4.77 |
| CHEMBL4789296 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754280 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4787337 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4746923 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4787528 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4760099 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL4776804 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL4796299 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4762564 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL4765212 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4758999 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL4784157 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL4758518 | — | IC50 | = | 10950.0 | nM | 4.96 |
| CHEMBL4794790 | — | IC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL4760249 | — | IC50 | = | 12490.0 | nM | 4.90 |
| CHEMBL4753647 | — | IC50 | = | 13080.0 | nM | 4.88 |
| CHEMBL4740881 | — | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL4790250 | — | IC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL4780025 | — | IC50 | = | 13820.0 | nM | 4.86 |
| CHEMBL4781138 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4755623 | — | IC50 | = | 14610.0 | nM | 4.83 |
| CHEMBL4794563 | — | IC50 | = | 15090.0 | nM | 4.82 |
| CHEMBL4782692 | — | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL4763269 | — | IC50 | = | 15310.0 | nM | 4.82 |
| CHEMBL4797207 | — | IC50 | = | 15030.0 | nM | 4.82 |
| CHEMBL4784929 | — | IC50 | = | 15610.0 | nM | 4.81 |
| CHEMBL4757769 | — | IC50 | = | 15360.0 | nM | 4.81 |
| CHEMBL4745640 | — | IC50 | = | 16740.0 | nM | 4.78 |
| CHEMBL4762094 | — | IC50 | = | 16890.0 | nM | 4.77 |
| CHEMBL4799029 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL4789296 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL4755610 | — | IC50 | = | 17760.0 | nM | 4.75 |
| CHEMBL4753481 | — | IC50 | = | 17990.0 | nM | 4.75 |
| CHEMBL4753539 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4758000 | — | IC50 | = | 17750.0 | nM | 4.75 |
| CHEMBL4760017 | — | IC50 | = | 17730.0 | nM | 4.75 |
| CHEMBL4743709 | — | IC50 | = | 18230.0 | nM | 4.74 |
| CHEMBL4799537 | — | IC50 | = | 18930.0 | nM | 4.72 |
| CHEMBL4741341 | — | IC50 | = | 18910.0 | nM | 4.72 |
| CHEMBL4794367 | — | IC50 | = | 19140.0 | nM | 4.72 |
| CHEMBL4797054 | — | IC50 | = | 19870.0 | nM | 4.70 |
| CHEMBL4759217 | — | IC50 | = | 20890.0 | nM | 4.68 |
| CHEMBL399121 | HESPERETIN | IC50 | = | 48590.0 | nM | 4.31 |