Assay Detail
Binding
CHEMBL4736788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R (unknown origin) by mobility shift assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR mutant cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.86 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744985 | — | — | 1 | 9.06 |
| CHEMBL4759112 | — | — | 1 | 9.06 |
| CHEMBL4759072 | — | — | 1 | 8.96 |
| CHEMBL4793338 | — | — | 1 | 8.96 |
| CHEMBL4759697 | — | — | 1 | 8.96 |
| CHEMBL4783641 | — | — | 1 | 8.92 |
| CHEMBL4794998 | — | — | 1 | 8.92 |
| CHEMBL4758842 | — | — | 1 | 8.66 |
| CHEMBL4758761 | — | — | 1 | 8.59 |
| CHEMBL4794670 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744985 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4759112 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4759072 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4793338 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4759697 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4783641 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4794998 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4758842 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4758761 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4794670 | — | IC50 | = | 2.9 | nM | 8.54 |