Assay Detail
Binding
CHEMBL4737004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSTP1-1 (unknown origin) using reduced GSH and CDNB as substrate incubated for 10 mins followed by substrate addition by microplate reader analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.51 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757438 | — | — | 1 | 6.80 |
| CHEMBL4763818 | — | — | 1 | 6.48 |
| CHEMBL4777228 | — | — | 1 | 6.38 |
| CHEMBL4797471 | — | — | 1 | 6.34 |
| CHEMBL4794932 | — | — | 1 | 6.30 |
| CHEMBL4748062 | — | — | 1 | 6.28 |
| CHEMBL4764480 | — | — | 1 | 6.27 |
| CHEMBL1234570 | — | — | 1 | 5.84 |
| CHEMBL4757338 | — | — | 1 | 5.39 |
| CHEMBL4783291 | — | — | 1 | 5.39 |
| CHEMBL4757112 | — | — | 1 | 5.30 |
| CHEMBL4743025 | — | — | 1 | 5.29 |
| CHEMBL4763865 | — | — | 1 | 5.19 |
| CHEMBL4762497 | — | — | 1 | 5.17 |
| CHEMBL4743365 | — | — | 1 | 5.07 |
| CHEMBL4739867 | — | — | 1 | 5.02 |
| CHEMBL4751148 | — | — | 1 | 5.01 |
| CHEMBL4787180 | — | — | 1 | 5.00 |
| CHEMBL4797735 | — | — | 1 | 4.99 |
| CHEMBL4762005 | — | — | 1 | 4.81 |
| CHEMBL4759134 | — | — | 1 | 4.54 |
| CHEMBL4742105 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757438 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4763818 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4777228 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4797471 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4794932 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4748062 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4764480 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1234570 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4757338 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4783291 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4757112 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4743025 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL4763865 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL4762497 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4743365 | — | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL4739867 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL4751148 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL4787180 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL4797735 | — | IC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL4762005 | — | IC50 | = | 15490.0 | nM | 4.81 |
| CHEMBL4759134 | — | IC50 | = | 28840.0 | nM | 4.54 |
| CHEMBL4742105 | — | IC50 | = | 35000.0 | nM | 4.46 |