Assay Detail
Functional
CHEMBL4737290
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.73 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759405 | — | — | 1 | 8.32 |
| CHEMBL4780210 | — | — | 1 | 8.25 |
| CHEMBL4776857 | — | — | 1 | 8.14 |
| CHEMBL4780562 | — | — | 1 | 7.99 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.92 |
| CHEMBL4753913 | — | — | 1 | 7.89 |
| CHEMBL4797445 | — | — | 1 | 7.89 |
| CHEMBL4754147 | — | — | 1 | 7.86 |
| CHEMBL4781016 | — | — | 1 | 7.85 |
| CHEMBL4763270 | — | — | 1 | 7.83 |
| CHEMBL4785943 | — | — | 1 | 7.82 |
| CHEMBL4751431 | — | — | 1 | 7.74 |
| CHEMBL4791300 | — | — | 1 | 7.58 |
| CHEMBL4752197 | — | — | 1 | 7.55 |
| CHEMBL4762282 | — | — | 1 | 7.42 |
| CHEMBL4758958 | — | — | 1 | 7.33 |
| CHEMBL4753608 | — | — | 1 | 7.28 |
| CHEMBL4790553 | — | — | 1 | 7.16 |
| CHEMBL4741266 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759405 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4780210 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4776857 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4780562 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL554 | LAPATINIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4753913 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4797445 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4754147 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4781016 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL4763270 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4785943 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4751431 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL4791300 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL4752197 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL4762282 | — | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL4758958 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL4753608 | — | IC50 | = | 52.1 | nM | 7.28 |
| CHEMBL4790553 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL4741266 | — | IC50 | = | 93.6 | nM | 7.03 |