Assay Detail
Binding
CHEMBL4737325
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Inhibition of EGFR T790M mutant (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.23 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753913 | — | — | 1 | 6.64 |
| CHEMBL4759405 | — | — | 1 | 6.37 |
| CHEMBL4790553 | — | — | 1 | 6.18 |
| CHEMBL4780210 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753913 | — | IC50 | = | 226.7 | nM | 6.64 |
| CHEMBL4759405 | — | IC50 | = | 422.25 | nM | 6.37 |
| CHEMBL4790553 | — | IC50 | = | 655.6 | nM | 6.18 |
| CHEMBL4780210 | — | IC50 | = | 1887.2 | nM | 5.72 |