Assay Detail
Functional
CHEMBL4737347
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Agonist activity at FPR2 (unknown origin) by calcium mobilization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.12 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794375 | — | — | 1 | 9.60 |
| CHEMBL4785302 | — | — | 1 | 9.06 |
| CHEMBL4747556 | — | — | 1 | 8.54 |
| CHEMBL4755656 | — | — | 1 | 8.00 |
| CHEMBL562380 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794375 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4785302 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4747556 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4755656 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL562380 | — | EC50 | = | 3800.0 | nM | 5.42 |