Assay Detail
Functional
CHEMBL4737384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SHSY-5Y cells assessed as growth inhibition after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764301 | — | — | 1 | 6.00 |
| CHEMBL4782703 | — | — | 1 | 5.96 |
| CHEMBL4746836 | — | — | 1 | 5.77 |
| CHEMBL4741315 | — | — | 1 | 5.64 |
| CHEMBL4278654 | — | — | 1 | 5.25 |
| CHEMBL3560171 | — | — | 1 | 4.75 |
| CHEMBL1231132 | — | — | 1 | - |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764301 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4782703 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4746836 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4741315 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4278654 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3560171 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1231132 | — | IC50 | - | — | - | |
| CHEMBL306823 | SODIUM DICHLOROACETATE | IC50 | = | 17400000.0 | nM | - |