Assay Detail
Functional
CHEMBL4737386
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Antiproliferative activity against human A375 cells assessed as growth inhibition after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.65 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764301 | — | — | 1 | 6.05 |
| CHEMBL4782703 | — | — | 1 | 6.05 |
| CHEMBL4746836 | — | — | 1 | 5.96 |
| CHEMBL4741315 | — | — | 1 | 5.75 |
| CHEMBL4278654 | — | — | 1 | 5.31 |
| CHEMBL3560171 | — | — | 1 | 4.77 |
| CHEMBL1231132 | — | — | 1 | - |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764301 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4782703 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4746836 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4741315 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4278654 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3560171 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1231132 | — | IC50 | - | — | - | |
| CHEMBL306823 | SODIUM DICHLOROACETATE | IC50 | = | 20100000.0 | nM | - |