Assay Detail
Binding
CHEMBL4737525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat RXFP1 expressed in human HEK296 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.88 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754949 | — | — | 1 | 9.30 |
| CHEMBL4793799 | — | — | 1 | 9.05 |
| CHEMBL4781560 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754949 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4793799 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4781560 | — | EC50 | = | 5.3 | nM | 8.28 |