Assay Detail
Binding
CHEMBL4738677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization in human HeLa cells assessed as dynamic tyrosinated microtubules content by incubated for 2 hrs by immunofluorescence staining based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.35 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.70 |
| CHEMBL4780261 | — | — | 1 | 6.28 |
| CHEMBL4785381 | — | — | 1 | 6.26 |
| CHEMBL4753697 | — | — | 1 | 6.14 |
| CHEMBL4762961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4780261 | — | EC50 | = | 523.0 | nM | 6.28 |
| CHEMBL4785381 | — | EC50 | = | 555.0 | nM | 6.26 |
| CHEMBL4753697 | — | EC50 | = | 717.0 | nM | 6.14 |
| CHEMBL4762961 | — | EC50 | > | 10000.0 | nM | - |