Assay Detail
Binding
CHEMBL4739016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CLK2 using YRRAAVPPSPSLSR substrate by radiometric scintillation assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4762964 | — | — | 1 | 7.80 |
| CHEMBL4797457 | — | — | 1 | 7.80 |
| CHEMBL4754195 | — | — | 1 | 7.70 |
| CHEMBL4750420 | — | — | 1 | 7.60 |
| CHEMBL4789951 | — | — | 1 | 7.43 |
| CHEMBL4743939 | — | — | 1 | 7.41 |
| CHEMBL4743730 | — | — | 1 | 7.40 |
| CHEMBL4790030 | — | — | 1 | 7.14 |
| CHEMBL4791451 | — | — | 1 | 7.05 |
| CHEMBL4740998 | — | — | 1 | 6.81 |
| CHEMBL4790791 | — | — | 1 | 6.75 |
| CHEMBL4778370 | — | — | 1 | 6.28 |
| CHEMBL4741919 | — | — | 1 | 6.18 |
| CHEMBL4794825 | — | — | 1 | 6.08 |
| CHEMBL4777288 | — | — | 1 | 5.85 |
| CHEMBL4789373 | — | — | 1 | 5.73 |
| CHEMBL4777540 | — | — | 1 | - |
| CHEMBL4758047 | — | — | 1 | - |
| CHEMBL4747210 | — | — | 1 | - |
| CHEMBL4790254 | — | — | 1 | - |
| CHEMBL4800422 | — | — | 1 | - |
| CHEMBL4793177 | — | — | 1 | - |
| CHEMBL4777533 | — | — | 1 | - |
| CHEMBL4747520 | — | — | 1 | - |
| CHEMBL4795812 | — | — | 1 | - |
| CHEMBL4778153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4762964 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4797457 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4754195 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4750420 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4789951 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4743939 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4743730 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4790030 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4791451 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4740998 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4790791 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4778370 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL4741919 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL4794825 | — | IC50 | = | 827.0 | nM | 6.08 |
| CHEMBL4777288 | — | IC50 | = | 1427.0 | nM | 5.85 |
| CHEMBL4789373 | — | IC50 | = | 1845.0 | nM | 5.73 |
| CHEMBL4777540 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4758047 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747210 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4790254 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4800422 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4793177 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4777533 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747520 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4795812 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4778153 | — | IC50 | > | 3000.0 | nM | - |