Assay Detail
Binding
CHEMBL4739019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length recombinant DYRK1A using RRRFRPASPLRGPP substrate by radiometric scintillation assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.56 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4762964 | — | — | 1 | 6.94 |
| CHEMBL4789951 | — | — | 1 | 6.86 |
| CHEMBL4797457 | — | — | 1 | 6.83 |
| CHEMBL4754195 | — | — | 1 | 6.67 |
| CHEMBL4791451 | — | — | 1 | 6.49 |
| CHEMBL4741919 | — | — | 1 | 6.25 |
| CHEMBL4743730 | — | — | 1 | 5.86 |
| CHEMBL4777288 | — | — | 1 | - |
| CHEMBL4740998 | — | — | 1 | - |
| CHEMBL4789373 | — | — | 1 | - |
| CHEMBL4794825 | — | — | 1 | - |
| CHEMBL4778370 | — | — | 1 | - |
| CHEMBL4777540 | — | — | 1 | - |
| CHEMBL4758047 | — | — | 1 | - |
| CHEMBL4747210 | — | — | 1 | - |
| CHEMBL4790254 | — | — | 1 | - |
| CHEMBL4800422 | — | — | 1 | - |
| CHEMBL4793177 | — | — | 1 | - |
| CHEMBL4777533 | — | — | 1 | - |
| CHEMBL4747520 | — | — | 1 | - |
| CHEMBL4795812 | — | — | 1 | - |
| CHEMBL4778153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4762964 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4789951 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4797457 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4754195 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4791451 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL4741919 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL4743730 | — | IC50 | = | 1368.0 | nM | 5.86 |
| CHEMBL4777288 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4740998 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4789373 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4794825 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4778370 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4777540 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4758047 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747210 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4790254 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4800422 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4793177 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4777533 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4747520 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4795812 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4778153 | — | IC50 | > | 3000.0 | nM | - |