Assay Detail
Binding
CHEMBL4739028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CLK4 (unknown origin) by NanoBRET cellular target engagement assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK4 (CHEMBL4203) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.37 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778153 | — | — | 1 | 4.40 |
| CHEMBL4777288 | — | — | 1 | 4.34 |
| CHEMBL3894571 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778153 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4777288 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3894571 | — | IC50 | > | 3000.0 | nM | - |