Assay Detail
Binding
CHEMBL4739212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to EED (unknown origin) assessed as dissociation constant by SPR analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.81 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755618 | — | — | 1 | 6.40 |
| CHEMBL4759335 | — | — | 1 | 6.30 |
| CHEMBL4754048 | — | — | 1 | 5.92 |
| CHEMBL4762963 | — | — | 1 | 5.62 |
| CHEMBL4748924 | — | — | 1 | 4.82 |
| CHEMBL4785927 | — | — | 1 | - |
| CHEMBL4752420 | — | — | 1 | - |
| CHEMBL4792277 | — | — | 1 | - |
| CHEMBL4751508 | — | — | 1 | - |
| CHEMBL4763811 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755618 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL4759335 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4754048 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL4762963 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL4748924 | — | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL4785927 | — | Kd | - | — | - | |
| CHEMBL4752420 | — | Kd | = | 305000.0 | nM | - |
| CHEMBL4792277 | — | Kd | - | — | - | |
| CHEMBL4751508 | — | Kd | - | — | - | |
| CHEMBL4763811 | — | Kd | - | — | - |