Assay Detail
Binding
CHEMBL4742450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of haspin in human SW620 cells assessed as reduction in IFNgamma-induced H3T3 phosphorylation pre-incubated for 1 hr before IFNgamma stimulation for 3 hrs by Western blot analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase haspin (CHEMBL1075163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Condensed tricyclic compounds as protein kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| INH | 8 | - | - |
| IC50 | 1 | 8.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4791276 | — | — | 1 | 8.80 |
| CHEMBL4779550 | — | — | 1 | - |
| CHEMBL4790936 | — | — | 1 | - |
| CHEMBL4777501 | — | — | 1 | - |
| CHEMBL4778840 | — | — | 1 | - |
| CHEMBL4782696 | — | — | 1 | - |
| CHEMBL4781993 | — | — | 1 | - |
| CHEMBL4793477 | — | — | 1 | - |
| CHEMBL4782203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4791276 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4779550 | — | INH | < | 500.0 | nM | - |
| CHEMBL4790936 | — | INH | < | 500.0 | nM | - |
| CHEMBL4777501 | — | INH | < | 500.0 | nM | - |
| CHEMBL4778840 | — | INH | < | 500.0 | nM | - |
| CHEMBL4782696 | — | INH | < | 500.0 | nM | - |
| CHEMBL4781993 | — | INH | < | 500.0 | nM | - |
| CHEMBL4793477 | — | INH | < | 500.0 | nM | - |
| CHEMBL4782203 | — | INH | < | 500.0 | nM | - |