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Assay Detail

CHEMBL4742624

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MEKK2- induced activation of MKK4/(unknown origin) using JNK1 as substrate in presence of [gamma-33P]-ATP by scintillation counter assay
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dual specificity mitogen-activated protein kinase kinase 4 (CHEMBL2897) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 6.07 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4796882 — — 1 6.30
CHEMBL4797449 — — 1 6.30
CHEMBL4798975 — — 1 6.30
CHEMBL4781930 — — 1 6.30
CHEMBL4797480 — — 1 6.30
CHEMBL4783187 — — 1 6.30
CHEMBL4779231 — — 1 6.30
CHEMBL4785015 — — 1 6.30
CHEMBL4782457 — — 1 6.00
CHEMBL4797354 — — 1 6.00
CHEMBL4781410 — — 1 6.00
CHEMBL4797964 — — 1 6.00
CHEMBL4794368 — — 1 6.00
CHEMBL4800472 — — 1 6.00
CHEMBL4783282 — — 1 6.00
CHEMBL4781671 — — 1 6.00
CHEMBL4789177 — — 1 6.00
CHEMBL4784779 — — 1 6.00
CHEMBL4792739 — — 1 6.00
CHEMBL4786277 — — 1 6.00
CHEMBL4793390 — — 1 6.00
CHEMBL4780791 — — 1 6.00
CHEMBL4779611 — — 1 6.00
CHEMBL4793405 — — 1 6.00
CHEMBL4793605 — — 1 6.00
CHEMBL4777904 — — 1 6.00
CHEMBL4784132 — — 1 6.00
CHEMBL4791205 — — 1 6.00
CHEMBL4782205 — — 1 6.00
CHEMBL4797274 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4796882 — IC50 = 500.0 nM 6.30
CHEMBL4797449 — IC50 = 500.0 nM 6.30
CHEMBL4798975 — IC50 = 500.0 nM 6.30
CHEMBL4781930 — IC50 = 500.0 nM 6.30
CHEMBL4797480 — IC50 = 500.0 nM 6.30
CHEMBL4783187 — IC50 = 500.0 nM 6.30
CHEMBL4779231 — IC50 = 500.0 nM 6.30
CHEMBL4785015 — IC50 = 500.0 nM 6.30
CHEMBL4797964 — IC50 = 1000.0 nM 6.00
CHEMBL4781671 — IC50 = 1000.0 nM 6.00
CHEMBL4794368 — IC50 = 1000.0 nM 6.00
CHEMBL4800472 — IC50 = 1000.0 nM 6.00
CHEMBL4783282 — IC50 = 1000.0 nM 6.00
CHEMBL4789177 — IC50 = 1000.0 nM 6.00
CHEMBL4784779 — IC50 = 1000.0 nM 6.00
CHEMBL4792739 — IC50 = 1000.0 nM 6.00
CHEMBL4797354 — IC50 = 1000.0 nM 6.00
CHEMBL4797810 — IC50 = 1000.0 nM 6.00
CHEMBL4776558 — IC50 = 1000.0 nM 6.00
CHEMBL4783920 — IC50 = 1000.0 nM 6.00
CHEMBL4782457 — IC50 = 1000.0 nM 6.00
CHEMBL4781410 — IC50 = 1000.0 nM 6.00
CHEMBL4797274 — IC50 = 1000.0 nM 6.00
CHEMBL4782205 — IC50 = 1000.0 nM 6.00
CHEMBL4791205 — IC50 = 1000.0 nM 6.00
CHEMBL4784132 — IC50 = 1000.0 nM 6.00
CHEMBL4777904 — IC50 = 1000.0 nM 6.00
CHEMBL4793605 — IC50 = 1000.0 nM 6.00
CHEMBL4793405 — IC50 = 1000.0 nM 6.00
CHEMBL4779611 — IC50 = 1000.0 nM 6.00
CHEMBL4780791 — IC50 = 1000.0 nM 6.00
CHEMBL4793390 — IC50 = 1000.0 nM 6.00
CHEMBL4786277 — IC50 = 1000.0 nM 6.00
CHEMBL4798539 — IC50 >= 10000.0 nM -
CHEMBL4783154 — IC50 >= 10000.0 nM -
CHEMBL4791513 — IC50 >= 10000.0 nM -
CHEMBL4799858 — IC50 - — -
CHEMBL4780999 — IC50 < 500.0 nM -
CHEMBL4785173 — IC50 - — -
CHEMBL4786956 — IC50 - — -
CHEMBL4786785 — IC50 < 500.0 nM -
CHEMBL4800064 — IC50 - — -
CHEMBL4800052 — IC50 - — -
CHEMBL4784675 — IC50 - — -
CHEMBL4795907 DARIZMETINIB IC50 - — -
CHEMBL4796421 — IC50 - — -
CHEMBL4786981 — IC50 - — -
CHEMBL4800447 — IC50 - — -
CHEMBL4800134 — IC50 - — -
CHEMBL4778758 — IC50 - — -